Analyses were conducted from January 1 to July 31, 2020.Įxposures Hormonal risk factors and family history of breast cancer. Pathology medical records on breast biopsies were obtained for the participants, and BBD subtypes were classified according to the latest European guidelines. All participants had complete follow-up through high-quality Swedish national registers until December 31, 2015. Participants took part in a comprehensive questionnaire on recruitment. Objective To investigate the risk of BBDs by age, hormonal factors, and family history of breast cancer.ĭesign, Setting, and Participants This retrospective cohort study assessed 70 877 women from the population-based Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA) who attended mammographic screening or underwent clinical mammography from January 1, 2011, to March 31, 2013, at 4 Swedish hospitals. Importance Benign breast diseases (BBDs) are common and associated with breast cancer risk, yet the etiology and risk of BBDs have not been extensively studied.
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